![]() ![]() ![]() This next step in the integrative methodology may help to better understand whether and which study-level factors drive the measures of effect. However, when there is substantial unaccounted heterogeneity in the outcome of interest across studies, it may be relevant to continue investigating whether such heterogeneity may be further explained by differences in characteristics of the studies (methodological diversity) or study populations (clinical diversity). Often times, a systematic review of literature stops after obtaining a meta-analytic aggregate measure of the parameter(s) of interest. Meta-regression is a statistical method that can be implemented following a traditional meta-analysis and can be regarded as an extension to it.
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